The singing genome: Core and region enriched gene expression define behaviorally regulated gene networks

ABSTRACT: Studies of transcriptional networks in multi-cellular organisms usually focus on isolated cells and typically assume that the discovered gene networks represent those present in connected cells within a complex organ like the brain. However, similar cell types connected in diverse anatomical networks could differentially influence transcriptional networks. Here, we used laser capture microdissection, expression arrays, genome mapping, and computational inference to explore behaviorally regulated gene networks in the brains of awake, behaving songbirds producing a skilled motor behavior, singing. We found that at baseline, in the absence of singing, a large proportion of genes (17%, >3000) are differentially expressed in the different brain regions of the neural circuit that controls singin

ORGANISM(S): Taeniopygia guttata

SUBMITTER: Andreas Pfenning 

PROVIDER: E-GEOD-33365 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress