Transcription profiling of spinal cord and oculomotor neurons from control and SOD1 mutant mice to test the hypothesis that the oculomotor neurons are intrinsically protected in amyotrophic lateral sclerosis

ABSTRACT: Amyotrophic lateral sclerosis (ALS) spares the ocular motor system. In this study, we tested the hypothesis that the oculomotor neurons are intrinsically protected in ALS. Using high-density cDNA microarrays, we examined the transcriptome of oculomotor nuclei and spinal cords in mice expressing a human mutant SOD1, the SOD1(G93A) ALS model, at 6 and 10 weeks of age. Comparison of gene expression profiles of these pre-symptomatic SOD1(G93A) mice showed a shift to a proapoptotic state in spinal cords, while the opposite was true in oculomotor nuclei. Seventeen members of the A, B, C and D Hox clusters increased in oculomotor nuclei from 6 to 10 weeks of age; 15 were downregulated in spinal cord. Although only the first 4 classes of a given Hox cluster (e.g., Hoxa1-4) are normally expressed i

ORGANISM(S): Mus musculus

SUBMITTER: Colleen McMullen 

PROVIDER: E-GEOD-3343 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress