Array CGH analysis of multiple myeloma (MM) and MGUS, Sapporo and Hiroshima samples

ABSTRACT: Multiple myeloma (MM) is a malignant plasma cell tumor characterized by various chromosomal aberrations. From the aspect of epigenetics, hypomethylation of DNA repetitive elements has been considered to induce chromosomal instability. We therefore have been interested in how it is related to chromosomal aberrations in MM. To address this, methylation levels of repetitive elements (including LINE-1, Alu and Satellite-alpha) and copy number alterations were measured in clinical samples (N=85). Bisulfite-pyrosequencing (N=85) and array-based comparative genomic hybridization (N=73) were used for these measurement, respectively. As results, methylation levels of repetitive elements were linearly associated with the degree of malignancy of plasma cells. Combined with hierarchical clustering of

ORGANISM(S): Homo sapiens

SUBMITTER: Masanori Nojima 

PROVIDER: E-GEOD-33685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress