Cross-species transcriptional networks in Diabetic Glomerulopathy in mouse and man

ABSTRACT: Murine models have been valuable instruments in defining the pathogenesis of diabetic nephropathy (DN), but they only partially recapitulate disease manifestations of human DN, limiting their utility . In order to define the molecular similarities and differences between human and murine DN, we performed a cross-species comparison of glomerular transcriptional networks. Glomerular gene expression was profiled in patients with early type 2 DN and in three mouse models (streptozotocin DBA/2 mice, db/db C57BLKS, and eNOS-deficient C57BLKS db/db mice). Species-specific transcriptional networks were generated and compared with a novel network-matching algorithm. Three shared, human-mouse cross-species glomerular transcriptional networks containing 143 (Human-STZ), 97 (Human- db/db), and 162

ORGANISM(S): Mus musculus

SUBMITTER: Viji Nair 

PROVIDER: E-GEOD-33744 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress