Vastus lateralis muscle gene expression after local physical deconditioning and exercise training

ABSTRACT: The leg of healthy volunteers was locally deconditioned using three weeks of unilateral lower limb suspension (ULLS). The extremely deconditioned legs of subjects with a spinal cord injury (SCI) were trained using eight weeks of functional electrical stimulation (FES) exercise, 2-3 times per week (total 20 sessions). These models for local (in)activity were used to study changes in gene expression level of: A) Long-term deconditioning: before FES versus before ULLS (=SCI versus control); B) Short-term deconditioning: after ULLS versus before ULLS; and C) Exercise training: after FES versus before FES. RNA was isolated from six healthy subjects before and after ULLS deconditioning, and three subjects with SCI before and after FES exercise training.

ORGANISM(S): Homo sapiens

SUBMITTER: Gerwen Lammers 

PROVIDER: E-GEOD-33886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress