Transcription profiling of skeletal muscle in TypeII diabetes patients to investigate mitochondrial dysfunction .

ABSTRACT: Skeletal muscle mitochondrial dysfunction is secondary to T2DM and can be improved by long-term regular exercise training Mitochondrial dysfunction has long been implicated to play a causative role in development of type 2 diabetes (T2DM). However, a growing number of recent studies provide data that mitochondrial dysfunction is a consequence of T2DM development. The aim of our study is to clarify in further detail the causal role of mitochondrial dysfunction in T2DM by a comprehensive ex vivo analysis of mitochondrial function combined with global gene expression analysis in muscle of pre-diabetic newly diagnosed untreated T2DM subjects and long-standing insulin treated T2DM subjects compared with age- and BMI-matched controls. In addition, we assessed the impact of long-term interval ex

ORGANISM(S): Homo sapiens

SUBMITTER: Florence van Tienen 

PROVIDER: E-GEOD-19420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress