TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle

ABSTRACT: substantial number of people at risk to develop type 2 diabetes could not improve insulin sensitivity by physical training intervention. We studied the mechanisms of this impaired exercise response in 20 middle-aged individuals who performed a controlled eight weeks cycling and walking training at 80 % individual VO2max. Participants identified as non-responders in insulin sensitivity (based on Matsuda index) did not differ in pre-intervention parameters compared to high responders. The failure to increase insulin sensitivity after training correlates with impaired up-regulation of mitochondrial fuel oxidation genes in skeletal muscle, and with the suppression of the upstream regulators PGC1α and AMPKα2. The muscle transcriptome of the non-responders is further characterized by an activa

ORGANISM(S): Homo sapiens

SUBMITTER: Johannes Beckers 

PROVIDER: E-GEOD-72462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress