Transcription profiling of soleus muscle from lean and obese Zucker rats following exercise training

ABSTRACT: Endurance exercise training has been shown to decrease whole-body and skeletal muscle insulin resistance and increase glucose tolerance in conditions of both pre-diabetes and overt type 2 diabetes. However, the adaptive responses in skeletal muscle at the molecular and genetic level for these beneficial effects of exercise training have not been clearly established in an animal model of pre-diabetes. The present study identifies alterations in skeletal muscle gene expression that occur with exercise training in pre-diabetic, insulin-resistant obese Zucker (fa/fa) rats and insulin-sensitive lean Zucker (Fa/-) rats. Treadmill running for up to 4 weeks caused significant enhancements of glucose tolerance as assessed by the integrated area under the curve for glucose (AUCg) during an oral g

ORGANISM(S): Rattus norvegicus

SUBMITTER: Erik Henriksen 

PROVIDER: E-TABM-213 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress