Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

ABSTRACT: Aging and its physiological manifestations have been correlated with adult stem cell exhaustion and a failure to maintain tissue homeostasis1-10. Since multiple morphological cellular defects are associated with aging-related disorders, we hypothesized that late onset disorders might be linked to adult stem cell abnormalities compromising cellular function over time. Our work shows that a dominant G2019S mutation in the human LRRK2 gene, which is associated with central nervous system disorders, including Parkinson’s disease, the second most prevalent neurodegenerative disease in the aging population, causes alterations in neural stem cell homeostasis in aging-related cellular contexts. They include disruption of the nuclear architecture, deficiencies in clonal expansion and alterations in

ORGANISM(S): Homo sapiens

SUBMITTER: Ulrich Wagner 

PROVIDER: E-GEOD-34061 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress