Early transcriptional changes linked to naturally occurring Huntington's disease mutations in human embryonic stem cells

ABSTRACT: Multiple human embryonic stem (ES) cell lines derived from blastocysts diagnosed as carrying the mutant huntingtin gene by pre-implantation diagnosis were used to explore early developmental changes in gene expression. How mutant huntingtin impacts on signalling pathways in the pre-symptomatic period has remained essentially unexplored in humans due to a previous lack of appropriate models. Total RNA was isolated from 10 human ES cell lines, 6 HD and 4 wild type control, and their neural stem cell (NSC) progeny.

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Giles 

PROVIDER: E-GEOD-34201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress