REST Couples Loss of Pluripotency with Neural Induction and Neural Differentiation

ABSTRACT: Neural differentiation of embryonic stem cells (ESCs) requires coordinated repression of the pluripotency regulatory programme and reciprocal activation of the neurogenic regulatory programme. Upon neural induction, ESCs rapidly repress expression of pluripotency genes followed by staged activation of neural progenitor and differentiated neuronal and glial genes. The transcriptional factors that underlie pluripotency are partially characterized, whereas those underlying neural induction are much less explored, and the factors that coordinate these two developmental programs are completely unknown. One transcription factor, REST (RE1 silencing transcription factor), has been linked with terminal differentiation of neural progenitors, and more recently and controversially, with control of pl

ORGANISM(S): Mus musculus

SUBMITTER: Caroline Johnston 

PROVIDER: E-GEOD-34244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress