Two Forkhead transcription factors regulate cardiac progenitor cell divisions by a Polo kinase-dependent pathway

ABSTRACT: The development of a complex organ requires the proper differentiation and production of appropriate numbers of each of its constituent cell types, as well as their correct positioning within the organ. During Drosophila cardiogenesis, all three of these processes are controlled by jumeau (jumu) and Checkpoint suppressor homologue (CHES-1-like), two genes encoding forkhead transcription factors that were discovered utilizing an integrated genetic, genomic and computational strategy which identified 70 novel genes expressed in the developing Drosophila heart. Both jumu and CHES-1-like are required during asymmetric cell division for the derivation of two distinct cardiac cell types from their mutual precursor, and in symmetric cell division to produce yet a third type of heart cell. jumu

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Shaad Ahmad 

PROVIDER: E-GEOD-34946 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress