Extensive conservation of ancient microsynteny across metazoans

ABSTRACT: Gene order, or microsynteny, is generally thought not to be conserved across metazoan phyla. Only a handful of exceptions, typically of tandemly duplicated genes such as Hox genes, have been discovered. Here, we performed a systematic survey for microsynteny conservation in 17 genomes and identified nearly 600 pairs of unrelated genes that have remained together across over 600 million years of evolution. Using multiple genome-wide resources, including several genomic features, epigenetic marks, sequence conservation and microarray expression data, we provide extensive evidence that many of these ancient microsyntenic arrangements have been conserved in order to preserve either (i) the coordinated transcription of neighboring genes, or (ii) Genomic Regulatory Blocks (GRBs), in which transc

ORGANISM(S): Danio rerio

SUBMITTER: Ozren Bogdanovic 

PROVIDER: E-GEOD-35050 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress