Transcription profile of adipose derived mesenchymal stem cells separated by cell surface protein N-cadherin.

ABSTRACT: Mesenchymal stem cells (MSCs) are one of most promising stem cell sources for regenerative medicine. MSCs have a differention ability into several tissues. However, their differentiation efficiency is considered quite limited. Especially, the differentiation efficiency into cardiomyocytes is very low. N-cadherin is one of the cell surface protein that is expressed in developing and adult cardiomyocytes. We found that cell surface expression of N-cadherin in MSCs shows good correlation with the cardiomyogenic differentiation ability. We also analyzed the expression profiles of N-cadherin-positive and N-cadherin-negative fraction by microarray. We found that N-cadherin-positive MSCs show higher expression of some of the cardiomyogenesis-related genes than N-cadherin-negative MSCs. The ASCs

ORGANISM(S): Homo sapiens

SUBMITTER: Hisako Ishimine 

PROVIDER: E-GEOD-35232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress