Transcriptome analysis of Newman delta2027

ABSTRACT: Intracellular small-molecule signaling has drawn increasing attention due to its importance in bacterial physiology and host-pathogen interactions. Here, we show that a new quinone-sensing transcriptional regulator, QsbR (quinone-stress sensing and bleomycin resistance regulator), is important for bacterial stress response and virulence in S. aureus. The mutant strain of qsbR exhibits dramatically reduced staphylococcal virulence in a murine abscess model of infection. Moreover, the qsbR mutant shows an accumulation of riboflavin and an increased resistance to quinone stress and bleomycin compared to the wild-type strain Newman. Microarray analysis confirmed that QsbR impacts the expression of genes that are involved in quinone stress response, bleomycin resistance, riboflavin biosynthesis

ORGANISM(S): Staphylococcus aureus subsp. aureus str. Newman

SUBMITTER: John Braisted 

PROVIDER: E-GEOD-35409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress