Sox9 mediated differential gene expression was assessed in prostaspheres derived from urogenital sinus epithelial cells

ABSTRACT: Prostate cancer is one of the most common malignancies and the second leading cause of death from cancer in men. The molecular mechanisms driving prostate carcinogenesis are complex; with several lines of evidence suggesting that the re-expression of conserved developmental programs play a key role. Through conditional gene targeting and organ grafting, we describe conserved roles for the transcription factor Sox9 in the initiation of both prostate organogenesis and prostate carcinogenesis in murine models. Abrogation of Sox9 expression prior to the initiation of androgen signaling blocks the initiation of prostate development. Similarly, Sox9 deletion in two genetic models of prostate cancer (TRAMP and Hi-Myc) blocks cancer initiation. Expression profiling of Sox9-null prostate epithelial

ORGANISM(S): Mus musculus

SUBMITTER: Luigi Marchionni 

PROVIDER: E-GEOD-35419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress