Genome-wide methylation in paired lung tumor/non-tumor samples using the HELP assay

ABSTRACT: In lung cancer, hypermethylation of specific gene promoters has been found during the progressive carcinogenesis. The identification of common methylation events will aid in the understanding of molecular events during neoplastic transformation and help develop biomarkers for cancer with high predictive and diagnostic value. To explore common methylation events on a genome-wide scale in lung cancer, we analyzed the methylation profiles of paired NSCLC tumor and far adjacent non-tumor samples using the HELP-microarray assay, which yields information on 1.2 million fragments throughout the genome. In this study, 24 pairs of tumor and adjacent non-tumor samples were analyzed using the HELP assay. At p = 5E-6, we identified 26,138 differentially methylated fragments (corresponding to 2 CpG sit

ORGANISM(S): Homo sapiens

SUBMITTER: Miao Shi 

PROVIDER: E-GEOD-35520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress