Notch controls the magnitude of CD4+ T cell responses by promoting cellular longevity

ABSTRACT: Generation of effective immune responses requires expansion of rare antigen-specific CD4+ T cells. The magnitude of the response is ultimately determined by proliferation and survival. Both processes are tightly controlled to limit responses to innocuous antigens. Sustained expansion occurs only when innate immune sensors are activated by microbial stimuli or by adjuvants, which has important implications for vaccination. The molecular identity of the signals controlling sustained T cell responses is not fully clear. Here we describe a prominent role for the Notch pathway in this process. Co-activation of Notch allows accumulation of far greater numbers of activated CD4+ T cells than stimulation via T cell receptor and classical co-stimulation alone. Notch does not overtly affect cell cycl

ORGANISM(S): Mus musculus

SUBMITTER: Derk Amsen 

PROVIDER: E-GEOD-35547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress