Nucleosome Position by MNase-seq from ENCODE/Stanford/BYU

ABSTRACT: Nucleosomes are part of the first level of chromatin packaging. They each consist of a histone heterooctamer around which DNA wraps 1.6 times. The histone heterooctomamer is made up of two copies of histones 2A, 2B, 3 and 5. The segment of DNA wrapped around the histones, the so-called "core" fragment, is 147 base pairs long. Neighboring nucleosomes are separated from one another by a stretch of DNA called the "linker," whose size varies depending on organism, cell type, and even chromatin activity. Certain chromatin remodeling factors govern accessibility of DNA to regulatory proteins by repositioning nucleosomes to reveal regulatory sites that would otherwise be occluded by a nucleosome. In contrast to histone modifications such as methylation or acetylation, which ar

ORGANISM(S): Homo sapiens

SUBMITTER: UCSC ENCODE DCC 

PROVIDER: E-GEOD-35586 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress