Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia

ABSTRACT: Polymorphonuclear cells (neutrophils) play an important role in the systemic inflammatory response syndrome and the development of sepsis. These cells are essential for the defense against microorganisms, but may also cause tissue damage. Therefore, neutrophil numbers and activity are considered to be tightly regulated. Previous studies have investigated gene transcription during experimental endotoxemia in whole blood and peripheral blood mononuclear cells. However, the gene transcription response of the circulating pool of neutrophils to systemic inflammatory stimulation in vivo is currently unclear. We examined neutrophil gene transcription kinetics in healthy human subjects (n=4) administered a single dose of endotoxin (LPS, 2 ng/kg iv). In addition, freshly isolated neutrophils were s

ORGANISM(S): Homo sapiens

SUBMITTER: Stan Kleijn 

PROVIDER: E-GEOD-35590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress