Transcription profiling of rat whole brain samples from animals with repeated exposure to the anaesthetic isoflurane
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ABSTRACT: 12 Controls, 3 5-exposures, 3 10-exposures. Rats were exposed to 90 minutes of 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania.
Project description:12 Controls, 3 5-exposures, 3 10-exposures. Rats were exposed to 90 minutes of 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords: time-course
Project description:Rats were exposed to 90 minutes of 0.8% halothane or 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords = anesthetics Keywords: other
Project description:Rats were exposed to 90 minutes of 0.8% halothane or 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania.
Project description:12 Controls, 3 5-exposures, 3 10-exposures. Rats were exposed to 90 minutes of 0.8% halothane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords: time-course
Project description:12 Controls, 3 5-exposures, 3 10-exposures. Rats were exposed to 90 minutes of 0.8% halothane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania.
Project description:This SuperSeries is composed of the following subset Series:; GSE357: Halothane Repetitive Exposure; GSE358: Isoflurane Repetitive Exposure; GSE752: Halothane/Isoflurane Repetitive Exposures Experiment Overall Design: Refer to individual Series
Project description:Interventions: isoflurane group;isoflurane-epidural group
Primary outcome(s): interleukins IL-6 , IL-10
Study Design: Parallel: different groups receive different interventions at same time during study,Randomised,simple randomisation using a randomisation table created by a computer software program,Sealed opaque envelopes
Project description:Fear conditioning in rats leads to long term memory (LTM) formation. A central neural substrate for LTM is the basolateral amygdala. We sought the expression changes specific to LTM at 6h following anesthesia with isoflurane (a general anesthetic and an effective amnestic agent), following pain (a component of conditioning), and following conditioning in presence and absence of isoflurane. Keywords = anesthesia, amygdala, LTM, Rampil, Isoflurane, fear, memory Keywords: other