Innate immunity and the evolution of resistance to an emerging infectious disease in a wild bird

ABSTRACT: Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild vertebrate populations. Here we used experimental infections and cDNA microarrays to examine whether changes in the innate and/or acquired immune responses likely accompanied the emergence of resistance in house finches (Carpodacus mexicanus) in the eastern United States subject to a recent outbreak of conjunctivitis-causing bacterium (Mycoplasma gallisepticum- MG). Three days following experimental infection with MG, we observed differences in the splenic transcriptional responses between House Finches from eastern U.S. populations, with a 12-year history of MG exposure, v

ORGANISM(S): Carpodacus mexicanus

SUBMITTER: Camille Bonneaud 

PROVIDER: E-GEOD-35931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress