Functional genomics of central nervous system and liver following herpes simplex virus corneal infection.

ABSTRACT: The overall goal of the study was to use in vivo data combined with functional genomics to define gene expression signatures representative of a spectrum of HSV CNS infections. Innate immune deficiencies result in a spectrum of severe clinical outcomes following infection. In particular, there is a strong association between loss of the signal transducer and activator of transcription (Stat) pathway, breach of the blood-brain barrier (BBB), and virus-induced neuropathology. The gene signatures that characterize resistance, disease, and mortality in the virus-infected nervous system have not been defined. Herpes simplex virus type 1 (HSV-1) is commonly associated with encephalitis in humans, and humans and mice lacking Stat1 display increased susceptibility to HSV central nervous system (CN

ORGANISM(S): Mus musculus

SUBMITTER: Richard Green 

PROVIDER: E-GEOD-35943 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress