Gene expression in hypoxia-tolerant Drosophila melanogaster

ABSTRACT: Hypoxia plays a key pathogenic role in the outcome of many pathologic conditions. To elucidate how organisms successfully adapt to hypoxia, a population of Drosophila melanogaster was generated, through an iterative selection process, that is able to complete its lifecycle at 4% O2, a level lethal to the starting parental population. Transcriptomic analysis of flies adapted for >200 generations was performed to identify pathways and processes that contribute to the adapted phenotype, comparing gene expression of three developmental stages with generation-matched control flies. A third group was included, hypoxia-adapted flies reverted to 21% O2 for five generations, to address the relative contributions of genetics and hypoxic environment to the gene expression differences. We identifi

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Merril Gersten 

PROVIDER: E-GEOD-36507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress