The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells

ABSTRACT: Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes as well as the regulation of host genes. Given the important role of miRNAs in regulating fundamental cellular processes, in this study we assayed changes in host miRNA expression during primary B cell infection by EBV. We observed and validated dynamic changes in several miRNAs from early proliferation through immortalization; oncogenic miRNAs were induced and tumor suppressor miRNAs were largely repressed. However, one miRNA described as a p53-targeted tumor suppressor, miR-34a, was strongly induced by EBV infection and expressed in many EBV and KSHV-infected lymphoma cell lines. The E

ORGANISM(S): Homo sapiens

SUBMITTER: Dereje Jima 

PROVIDER: E-GEOD-36926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress