Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stem Cell, Blood
SUBMITTER: Jessica Schira-Heinen
LAB HEAD: Kai Stuehler
PROVIDER: PXD016915 | Pride | 2020-01-31
REPOSITORIES: Pride
Schira-Heinen Jessica J Czapla Agathe A Hendricks Marion M Kloetgen Andreas A Wruck Wasco W Adjaye James J Kögler Gesine G Werner Müller Hans H Stühler Kai K Trompeter Hans-Ingo HI
Scientific reports 20200224 1
The contribution of microRNA-mediated posttranscriptional regulation on the final proteome in differentiating cells remains elusive. Here, we evaluated the impact of microRNAs (miRNAs) on the proteome of human umbilical cord blood-derived unrestricted somatic stem cells (USSC) during retinoic acid (RA) differentiation by a systemic approach using next generation sequencing analysing mRNA and miRNA expression and quantitative mass spectrometry-based proteome analyses. Interestingly, regulation of ...[more]