Ontology highlight
ABSTRACT:
ORGANISM(S): Candida glabrata
SUBMITTER: Jason Noble
PROVIDER: E-GEOD-37071 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Noble Jason A JA Tsai Huei-Fung HF Suffis Sara D SD Su Qin Q Myers Timothy G TG Bennett John E JE
Antimicrobial agents and chemotherapy 20121210 2
The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals (J. E. Bennett, K. Izumikawa, and K. A. Marr. Antimicrob. Agents Chemother. 48:1773-1777, 2004). Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter proteins and drug efflux. Studies in the related yeast Saccharomyces cerevisiae have shown that Pdr1p fo ...[more]