Gene expression data from time course of fin regeneration in Danio rerio (part 1)

ABSTRACT: Olsen et al (2010) have shown that induced Diabetes mellitus (DM) in adult Zebrafish results in an impairment of tissue regeneration as monitored by caudal fin regeneration. In those studies, streptozocin was used to induce hyperglycemia in adult zebrafish, and then, following streptozocin withdrawal, a recovery phase was allowed to re-establish euglycemia, due to pancreatic b-cell regeneration. DM-associated impaired fin regeneration continued indefinitely in the metabolic memory state (MM); allowing for subsequent molecular analysis of the underlying mechanisms of MM. This study focuses on elucidating the molecular basis explaining DM-associated impaired fin regeneration and why it persists into the MM state. The analysis of microarray data indicated that of the 14,900 transcripts analy

ORGANISM(S): Danio rerio

SUBMITTER: Alexey Leontovich 

PROVIDER: E-GEOD-37163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress