BET bromodomain inhibition suppresses TH17-mediated pathology

ABSTRACT: IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small molecule inhibitor, we show that the bromodomain and extra-terminal domain (BET) family of chromatin adaptors plays fundamental and selective roles in human and murine TH17 differentiation from naM-CM-/ve CD4+ T cells, as well as in the activation of previously differentiated TH17 cells. We provide evidence that BET controls TH17 differentiation in a bromodomain-dependent manner through a mechanism that includes the direct regulation of multiple effector TH17-associated cytokines, including IL17, IL

ORGANISM(S): Mus musculus

SUBMITTER: Barbara Bryant 

PROVIDER: E-GEOD-37270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress