Genome-wide analysis of three clonal neural stem cell lines derived from human foetal spinal cord tissue.

ABSTRACT: Stem cells have received substantial interest both for their potential as in vitro tools to study development and as potential therapeutic agents in a range of degenerative diseases of the nervous system. We have generated clonal neural stem cell lines from human foetal spinal cord conditionally immortalised with 4-hydroxy tamoxifen inducible cMyc (cMycERTAM), and performed a detailed assessment of their identity in terms of their expression of homeodomain transcription factors and their capacity to generate particular neuronal subtypes of the spinal cord. These lines retain a ventral spinal cord progenitor phenotype and give rise to electrically active neuronal subtypes characteristic of specific ventral progenitor subdomains. Upon grafting into lesioned rat spinal cord these cells differ

ORGANISM(S): Homo sapiens

SUBMITTER: Graham Cocks 

PROVIDER: E-GEOD-37282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress