Circadian clock drives novel functions through transcriptional cascade

ABSTRACT: Using larval zebrafish as a model system, we applied a genome-wide transcriptome approach that allowed us to investigate circadian gene expression that can be associated with various tissues and cell types. Our analysis of circadian gene regulatory network revealed a general principle: circadian clock controls diverse aspects of circadian physiology through transcriptional cascade of transcription factors (TFs). As a proof of this principle, we focused on microphthalmia-associated transcription factor a (mitfa), a dark-induced TF controlling melanogenesis in melanocytes. We demonstrated experimentally that there is a circadian rhythm of melanin synthesis mediated by mitfa. The circadian rhythm of mitfa is in turn driven by both endogenous clock and external light/dark cycle. The circadian

ORGANISM(S): Danio rerio

SUBMITTER: Haifang Wang 

PROVIDER: E-GEOD-37332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress