De Novo Purine Synthesis Mediates Circadian Control of Cell Cycle in Zebrafish (array)

ABSTRACT: Cell cycle and metabolism are two major outputs controlled by circadian rhythm in many organisms. Here we show that the three processes were linked through inosine 5'-phosphate dehydrogenase (impdh), a rate-limiting enzyme in de novo purine synthesis. We using adult zebrafish as a model system,we applied a genome-wide transcriptome approach that allowed us to investigate circadian gene expression. The whole-genome transcriptome profiles of adult brain in time-series were assayed on Agilent zebrafish microarrays. We used a similar statistical method to identify zebrafish circadian genes (ZCOG) as our previous study in larval zebrafish. Three isoforms of impdh show strong circadian oscillations in different tissues of zebrafish. impdh1a contributes to the ocular development and pigment synth

ORGANISM(S): Danio rerio

SUBMITTER: Guang Li 

PROVIDER: E-GEOD-51277 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress