Granulomatous response to Coxiella burnetii, the agent of Q fever: Activation of type I interferon-related genes

ABSTRACT: The formation of granulomas is associated with the resolution of Q fever, a zoonosis due to Coxiella burnetii; however the molecular mechanisms of granuloma formation remain poorly understood. We generated human granulomas with peripheral blood mononuclear cells and beads coated with C. burnetii, using BCG extracts as controls. A microarray analysis showed dramatic changes in gene expression in granuloma cells compared with peripheral blood mononuclear cells. About 60% of modulated genes were common to C. burnetii and BCG granulomas including M1-related genes. C. burnetii granulomas also expressed a specific transcriptional profile that was essentially enriched in genes associated with type I interferon response (IFI44, IFI44L, IFI6, OAS1, OAS2, OAS3, ISG15, IFIT1, IFITM2, IFITM3, MX1 and

ORGANISM(S): Homo sapiens

SUBMITTER: Julien Textoris 

PROVIDER: E-GEOD-37666 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress