Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

ABSTRACT: Critically ill intensive care unit (ICU) patients commonly develop severe muscle wasting and impaired muscle function, leading to delayed recovery, with subsequent increased morbidity and financial costs, and decrease quality of life of survivors. Acute Quadriplegic Myopathy (AQM) is one of the most common neuromuscular disorders associated with ICU-acquired muscle weakness. Although there are no available treatments for the ICU-acquired muscle weakness, it has been demonstrated that early mobilization can improve its prognosis and functional outcomes. This study aims at improving our understanding of the effects of passive mechanical loading on skeletal muscle structure and function by using a unique experimental rat ICU model allowing analyses of the temporal sequence of changes in mecha

ORGANISM(S): Rattus norvegicus

SUBMITTER: Monica Llano-Diez 

PROVIDER: E-GEOD-37944 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress