Mechanical loading and gene expression - Microarray study

ABSTRACT: Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify genes involved in the translation of mechanical stimuli into bone formation. The four-point bending model was used to induce a single period of mechanical loading (comprising 300 cycles (2 Hz) using a peak magnitude of 60 N) on the right tibia, while the contra lateral left tibia served as control. Six hours after loading, the effects of mechanical loading on gene-expression were determined with microarray analysis. Protein expression of differentially regulated genes was evaluated with immunoh

ORGANISM(S): Rattus norvegicus

SUBMITTER: Nathalie Bravenboer 

PROVIDER: E-GEOD-50707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress