Abnormal Developmental Control of Replication Timing Domains in Pediatric Acute Lymphoblastic Leukemia

ABSTRACT: Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication timing profiles for pediatric leukemias from 17 patients and 3 cell lines, as well as normal B and T cells. Non-leukemic EBV-transformed lymphoblastoid cell lines displayed highly stable replication timing profiles that were more similar to normal T cells than to leukemias. Leukemias were more similar to each other than to B and T cells but were considerably more heterogeneous than non-leukemic controls. Some differences were patient-specific while others were found in all leukemic samples, potentially representing early epigenetic events. Differences encompassed large segments of chromosomes and included genes implicated in other types

ORGANISM(S): Homo sapiens

SUBMITTER: Tyrone Ryba 

PROVIDER: E-GEOD-37987 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress