Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF

ABSTRACT: We evaluated two matched human cell lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment Analysis of microarray data identified a highly significant induction of oxidative phosphorylation gene set in MITF expressing cells compared to control cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Hans WIDLUND 

PROVIDER: E-GEOD-38007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress