Scaling proprioceptor gene transcription by retrograde NT3 signaling

ABSTRACT: Transcriptional analysis of identified DRG subpopulations. Cell-type specific intrinsic programs instruct neuronal subpopulations before target-derived factors influence later neuronal maturation. Retrograde neurotrophin signaling controls neuronal survival and maturation of dorsal root ganglion (DRG) sensory neurons, but how these potent signaling pathways intersect with transcriptional programs established at earlier developmental stages remains poorly understood. Here we determine the consequences of genetic alternation of NT3 signaling on genome-wide transcription programs in proprioceptors, an important sensory neuron subpopulation involved in motor reflex behavior. We find that the expression of many proprioceptor-enriched genes is dramatically altered by genetic NT3 elimination, ind

ORGANISM(S): Mus musculus

SUBMITTER: Tim Roloff 

PROVIDER: E-GEOD-38074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress