Transcription profiling of liver from wild type vs glycerol kinase knockout mice to understand the molecular pathogenesis of GKD

ABSTRACT: Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier genes, including other network partners. To understand the molecular pathogenesis of GKD, we performed microarray analysis on liver mRNA from neonatal glycerol kinase (Gyk) knockout (KO) and wild type (WT) mice. Unsupervised learning revealed the overall gene expression profile of the KO mice was different from that of WT. Real time PCR confirmed differences for selected genes. Functional gene enrichment analysis was used to find 56 increased and 37 decreased gene functional categories. Pathway Ass

ORGANISM(S): Mus musculus

SUBMITTER: Nicole Kim MacLennan 

PROVIDER: E-GEOD-3843 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress