Expression profiling of host genes altered after chemical-induced recurrent Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells

ABSTRACT: Seroepidemiological studies imply a correlation between Epstein-Barr virus (EBV) reactivation and the development of nasopharyngeal carcinoma (NPC). Phorbol esters, butyrates and N-nitroso compounds are known chemical carcinogens in foodstuffs and cigarettes that have been implicated as risk factors contributing to the development of NPC. We have demonstrated previously that low dose N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, 0.1 microg/ml) had a synergistic effect with 12-O-tetradecanoylphorbol-13-acetate (TPA) and sodium butyrate (SB) in enhancing EBV reactivation (Chem Biol Interact 188: 623-634). Since residents of areas with a high risk of NPC are reported to contact with these carcinogens (TPA, SB or nitrosamines) frequently, we sought to determine the consequence of repeated exposu

ORGANISM(S): Homo sapiens

SUBMITTER: Chih-Yeu Fang 

PROVIDER: E-GEOD-38453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress