Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of healthy human volunteers after consumin red wine vs. controls to investigate the cardioprotective effect of red wine

ABSTRACT: The aim of this study was to measure the influence of beverages on blood gene expression. We wanted to explore the underlying mechanisms of the cardioprotective effects of red wine. Experiment Overall Design: Six healthy volunteers participated in this randomized controlled cross-over experiment. On 4 independent days they had 4 different beverages (500mL each: grape juice, red wine, 40g diluted ethanol, water). Blood samples were taken at baseline, 1, 2, 4, 12 hours after the drink together with standardized nutrition. RNA of 120 PBL samples was hybridized on Affymetrix microarrays. Three sources of variations were examined: individual, time and beverage.

ORGANISM(S): Homo sapiens

SUBMITTER: Florent Baty 

PROVIDER: E-GEOD-3846 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analysis with respect to instrumental variables for the exploration of microarray data structures.

Baty Florent F   Facompré Michaël M   Wiegand Jan J   Schwager Joseph J   Brutsche Martin H MH  

BMC bioinformatics 20060929

<h4>Background</h4>Evaluating the importance of the different sources of variations is essential in microarray data experiments. Complex experimental designs generally include various factors structuring the data which should be taken into account. The objective of these experiments is the exploration of some given factors while controlling other factors.<h4>Results</h4>We present here a family of methods, the analyses with respect to instrumental variables, which can be easily applied to the pa  ...[more]

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