Temporal changes of gene expression in mouse heart, kidney and lung during juvenile growth

ABSTRACT: Temporal changes of gene expression from 1-wk- to 4-wk and 8-wk-old mouse in heart, kidney and lung. Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified >1600 genes that were regulated with age coordinately in kidney, lung, and heart of juvenile mice, including many genes that regulate proliferation. As examples, we focused on three growth-promoting genes, Igf2, Mest, and Peg3, that were markedly downregulated with age. We conclude that there exists an extensive genetic program occurring during postnat

ORGANISM(S): Mus musculus

SUBMITTER: Julian Lui 

PROVIDER: E-GEOD-38754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress