Transcriptome profiling of SOD1 mutant ALS model motor neurons.

ABSTRACT: Recent genetic studies of ALS patients have identified several forms of ALS that are associated with mutations in RNA binding proteins. In animals or cultured cells, such defects broadly affect RNA metabolism. This raises the question of whether all forms of ALS have general effects on RNA metabolism. We tested this hypothesis in a mouse model of ALS that is transgenic for a human disease-causing mutation in the enzyme superoxide dismutase 1 (SOD1). We analyzed RNA from laser-captured spinal cord motor neuron cell bodies of the mutant SOD1 strain, comparing the RNA profile with that from a corresponding wild-type SOD1 transgenic strain. We prepared the samples from animals that were presymptomatic, but which manifested abnormalities at the cellular level that are seen in ALS, includin

ORGANISM(S): Mus musculus

SUBMITTER: Justin Cotney 

PROVIDER: E-GEOD-38820 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress