Systematic dissection of roles for chromatin regulators in a yeast stress response

ABSTRACT: Packaging of eukaryotic genomes into chromatin has wide-ranging effects on gene transcription. Curiously, it is commonly observed that deletion of a global chromatin regulator affects expression of only a limited subset of genes bound to or modified by the regulator in question. However, in many single-gene studies it has become clear that chromatin regulators often do not affect steady-state transcription, but instead are required for normal transcriptional reprogramming by environmental cues. We therefore have systematically investigated the effects of 83 histone mutants, and 119 deletion mutants, on induction/repression dynamics of 200 transcripts in response to diamide stress in yeast. Importantly, we find that chromatin regulators play far more pronounced roles during gene induction/r

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Nir Friedman 

PROVIDER: E-GEOD-39080 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress