Double-stranded RNA induces molecular and inflammatory signatures that are directly relevant to COPD

ABSTRACT: Polyinosinic:polycytidylic acid (poly I:C) is a synthetic analogue of double-stranded (ds)RNA, a molecular pattern associated with viral infections, that is used to exacerbate inflammation in lung injury models. Despite its frequent use, there are no detailed studies of the responses elicited by a single topical administration of poly I:C to the lungs of mice. Our data provides the first demonstration that the molecular responses in the airways induced by poly I:C correlate to those observed in the lungs of COPD patients. These expression data also revealed three distinct phases of response to poly I:C, consistent with the changing inflammatory cell infiltrate in the airways. Poly I:C induced increased numbers of neutrophils and NK cells in the airways, which were blocked by CXCR2 and

ORGANISM(S): Mus musculus

SUBMITTER: Sriram Sridhar 

PROVIDER: E-GEOD-39304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress