Transcriptome Analysis of Renal Ischemia/Reperfusion Injury and its Modulation by Ischemic Pre-Conditioning or Hemin treatment

ABSTRACT: We examined, through an oligonucleotide microarray protocol, the renal differential transcriptome profiles of mices submitted to IRI, IPC and Hemin treatment. After identifying the profiles of differentially expressed genes observed for each comparison, we carried out functional enrichment analysis to reveal transcripts putatively involved in potential relevant biological processes and signaling pathways. The most relevant enriched biological processes found in these comparisons were stress, inflammation, apoptosis, pathways in cancer, differentiation, angiogenesis, focal adhesion, ECM-receptor interaction, ion transport, angiogenesis, mitosis and cell cycle, inflammatory response, olfactory transduction and regulation of actin cytoskeleton. In addition, the most important overrepresented

ORGANISM(S): Mus musculus

SUBMITTER: Hatylas Azevedo 

PROVIDER: E-GEOD-39548 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress