Global Gene Expression in Deceased Donor Liver Transplantation with Ischemic Preconditioning

ABSTRACT: The clear benefits of ischemic preconditioning (IPC) in reducing ischemia reperfusion injury (IRI) remain indistinct in human liver transplantation. To further understand the mechanistic aspects of IPC in human deceased donor liver transplantation (DDLT), we performed microarray analyses to determine global gene expression profiles associated with IPC administration. Donor and recipient characteristics in both groups were comparable. Clinical data from our study subset and larger trial were similar. IPC increased expression of 10 transcripts at either time point with roles in: antioxidant defenses, immunological response, lipid biosynthesis, and xenobiotic metabolism. IPC decreased the expression of 1 cell development related transcript. Conclusions: 1) IPC in DDLT increased the express

ORGANISM(S): Homo sapiens

SUBMITTER: George Dikdan 

PROVIDER: E-GEOD-15480 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress