Gene expression profile in human orthotopic liver transplantation

ABSTRACT: We have studied the genes activated in human liver transplantation to identify potential target genes for the prevention or treatment of related injuries. In a first protocol, in order to evaluate the effect of Ischemia-Reperfusion Injury (IRI) on gene expression profile, we compared gene expression levels in transplanted-reperfused livers versus basal values in donor livers, identifying 795 genes significantly modified in human liver after transplantation. Some genes are likely to be completely activated by IRI, as they are not expressed at all in basal livers. In a second protocol, in order to identify gene dysregulations already present in donor livers, which might affect gene expression profile after transplantation, gene expression evaluated in the first study was compared to contr

ORGANISM(S): Homo sapiens

SUBMITTER: Lucio Nitsch 

PROVIDER: E-GEOD-14951 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress