Molecular Signatures of Neurogenesis in the Hippocampal Subgranular Zone of Rodents

ABSTRACT: We sought to find molecular signatures of the SGZ cell types, and to characterize the molecular pathways and transcription factor cascades that define the neurogenic niche. We used laser capture microdissection and DNA microarrays to profile gene expression in the inner (SGZ) and outer portions of the dentate gyrus (DG). Since the vast majority of the cells in the DG are mature granule cells, we compared the expression of the inner and outer portions to reveal molecular markers for the less numerous populations of the SGZ. This data set is part of a larger study assessing conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Using a combination of selective SGZ transcriptional profiling with laser microdissection and DNA microarrays a

ORGANISM(S): Mus musculus

SUBMITTER: Jeremy Miller 

PROVIDER: E-GEOD-39697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress