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Microdissected brain tissue Alzheimer's

ABSTRACT: we explored the proteome of the area where they are located; the outer two-thirds of the molecular layer of the dentate gyrus. This area was microdissected from five subjects with Alzheimer disease and five non-demented controls, and quantitative mass spectrometry of pre-fractionated samples was performed.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Georgios Mermelekas

LAB HEAD: Janne Lehtio

PROVIDER: PXD014557 | Pride | 2019-11-11

REPOSITORIES: Pride

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The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.

Haytural Hazal H Mermelekas Georgios G Emre Ceren C Nigam Saket Milind SM Carroll Steven L SL Winblad Bengt B Bogdanovic Nenad N Barthet Gaël G Granholm Ann-Charlotte AC Orre Lukas M LM Tjernberg Lars O LO Frykman Susanne S

Molecular & cellular proteomics : MCP 20191107 1

Synaptic dysfunction is an early pathogenic event in Alzheimer disease (AD) that contributes to network disturbances and cognitive decline. Some synapses are more vulnerable than others, including the synapses of the perforant path, which provides the main excitatory input to the hippocampus. To elucidate the molecular mechanisms underlying the dysfunction of these synapses, we performed an explorative proteomic study of the dentate terminal zone of the perforant path. The outer two-thirds of th ...[more]

PMID: 31699905

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